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Hansson O, Petersén Å, Leist M, Nicotera P, Castilho RF and Brundin P.Proceedings of the National Academy of Sciences USA 96: 8727-8732 (1999)AbstractHuntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant HD gene mediates a slowly progressing striatal neuro

https://www.huntington-research.lu.se/transgenic-mice-expressing-huntingtons-disease-mutation-are-resistant-quinolinic-acid-induced - 2026-01-17

Petersén Å, Emgård M and Brundin P.Brain Research Bulletin 50: 275-281 (1999)AbstractThe survival of grafted embryonic striatal tissue, dissected from the lateral ganglionic eminence, depends on the status of the host striatum. We found significantly larger volumes of surviving graft tissue and of striatal-like tissue (P-zone) within the graft, when the host striatum had been subjected to an excit

https://www.huntington-research.lu.se/impact-preceding-excitotoxic-lesion-and-treatment-ciliary-neurotrophic-factor-striatal-graft - 2026-01-17

Petersén Å and Brundin P.Experimental Neurology 160: 402-412 (1999)AbstractCiliary neurotrophic factor (CNTF) has a protective effect on the striatum in animal models of Huntington's disease. However, the mechanism through which it exerts its effect is not clear. In this study, we show that there is a concentration-dependent direct protective effect of CNTF against N-methyl-D-aspartate-mediated ex

https://www.huntington-research.lu.se/effect-cntf-and-calcium-ionophore-a23187-induced-death-cultured-embryonic-stratal-neurons - 2026-01-17

Petersén Å, Mani K and Brundin P.Experimental Neurology 157: 1-18 (1999)AbstractWe review recent advances regarding the pathogenesis of Huntington's disease (HD). This genetic neurodegenerative disorder is caused by an expanded CAG repeat in a gene coding for a protein, with unknown function, called huntingtin. There is selective death of striatal and cortical neurons. Both in patients and a trans

https://www.huntington-research.lu.se/recent-advances-pathogenesis-huntingtons-disease - 2026-01-17

Baldo B, Gabery S, Soylu-Kucharz R, Cheong RY, Henningsen JB, Englund E, McLean C, Kirik D, Halliday G and Petersén Å.Neuropathology and Applied Neurobiology 45 (4): 361-379 (2019)AbstractAIMS:Metabolic dysfunction is involved in modulating the disease process in Huntington disease (HD) but the underlying mechanisms are not known. The aim of this study was to investigate if the metabolic regulator

https://www.huntington-research.lu.se/sirt1-increased-affected-brain-regions-and-hypothalamic-metabolic-pathways-are-altered-huntington - 2026-01-17

Brundin P, Petersén Å and Hansson O.Journal of Neurosurgery 90: 804-806 (1999)No abstract available; this is a letter to the editor.The letter 

https://www.huntington-research.lu.se/graft-survival - 2026-01-17

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Lundh SH, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA and Jakobsson J.Cell Reports 24(6): 1397-1406 (2018)AbstractMany neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences o

https://www.huntington-research.lu.se/huntingtin-aggregation-impairs-autophagy-leading-argonaute-2-accumulation-and-global-microrna - 2026-01-17

Fjalldal S, Follin C, Svärd D, Rylander L, Gabery S, Petersen Å, Van Westen D, Sundgren P, Bjorkman-Burtscher I, Lätt J, Ekman B, Johanson A and Erfurth EM.European Journal of Endocrinology 178 (6): 577-587 (2018)AbstractCONTEXT:Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.OBJECTIVE:To determine whether th

https://www.huntington-research.lu.se/microstructural-white-matter-alterations-and-hippocampal-volumes-are-associated-cognitive-deficits - 2026-01-17

Gawlik KI1, Harandi VM2, Cheong RY3, Petersén Å3, Durbeej M2.1Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.2Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.3Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.Matrix Biology 70: 36-79 (20

https://www.huntington-research.lu.se/laminin-a1-reduces-muscular-dystrophy-dy2j-mice - 2026-01-17

Vercruysse P, Vieau D, Blum D, Petersén Å and Dupuis L.Frontiers in Molecular Neuroscience 11:2 (2018)AbstractNeurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington's disease (HD), or co

https://www.huntington-research.lu.se/hypothalamic-alterations-neurodegenerative-diseases-and-their-relation-abnormal-energy-metabolism - 2026-01-17

Please note, that all links on this page open a new webpage. Knut and Alice Wallenberg FoundationThrough the research program Wallenberg Clinical Scholars, the Knut and Alice Wallenberg Foundation are funding 24 of the foremost clinical researchers in Sweden. Almost SEK 800 million are used for funding over ten years. Åsa Petersén was appointed Wallenberg Clinical Scholar 2020 and will receive SEK

https://www.huntington-research.lu.se/funding - 2026-01-17

Join our panel and help us get better We want you to have a good experience using our search systems or other services or visiting our Library. To achieve this, we need your help. Join our panel and take part in a study. You will receive a gift as a thank-you for your time. The University Library handles most of the search systems you use for books and digital materials. To develop the systems and

https://www.ub.lu.se/en/contact/help-us-improve-library - 2026-01-17

Manuscripts, images, maps and rare prints We are continually working on making our collections digitally available Explore the special collections We continually digitise manuscripts, images, maps, and rare prints from our collections and make them freely accessible online.Below you can browse among a selection of categories and collections or browse among different subjects and scientific discipl

https://www.ub.lu.se/en/find/digital-collections - 2026-01-17

Discover the width of our collections  Below you can browse among a selection of subjects and scientific disciplines, from astronomy to zoology.The collections of Lund University Library have been growing for 350 years and span the entire spectrum of human knowledge. Our ambition is to make our digital collections reflect this width, so that they can be used and enjoyed by as many as possible – by

https://www.ub.lu.se/en/find/digital-collections/digital-collections-subjects - 2026-01-17

Our digital collections are constantly growing. Though focusing on old, rare, and fragile documents, our ambition is also to create digital collections that reflect the diversity and richness of our physical collections, comprising manuscripts, maps, and printed books as well as photographs and images. Our ambitions are: To increase access – digitisation makes our collections available to everyone

https://www.ub.lu.se/en/find/digital-collections/about-digital-collections - 2026-01-17

Read- and publish agreement Researchers at Lund University can use agreements to publish open access with easy handling of the administrative processes and negotiated costs. Read more about the terms of the agreement here. About the agreementThe agreement provides open access publishing under negotiated conditions in journals from Taylor & Francis. Both open access journals and hybrid journals are

https://www.ub.lu.se/en/publish/open-access/publishing-agreements-and-discounts/taylor-francis - 2026-01-17

Through different types of publishing agreements, researchers at Lund University can publish open access with easier handling of the administrative processes and with negotiated costs. On this page you find out about what agreements you can use, and how. Publishing agreements for open access Through national agreements, negotiated by the National Library of Sweden, researchers at Lund University c

https://www.ub.lu.se/en/publish/open-access/publishing-agreements-and-discounts - 2026-01-17

REGISTER, PUBLISH AND MAKE YOUR DISSERTATION VISIBLE Here you find compiled information for doctoral students at Lund University about the procedure for registering, publishing and making their doctoral theses visible. Theses written at Lund University require ISBN number. Depending on which faculty and institution you belong to, you may order ISBN either from your faculty or from the University L

https://www.ub.lu.se/en/publish/doctoral-theses - 2026-01-17

Registration in LUCRIS and adding a full text As a doctoral student at LU, you use LUCRIS to register your degree project and the thesis. The registration makes the thesis visible in LU's Research Portal and on the university's calendar for upcoming defenses. Also, make the theses freely available whenever possible. Register your doctoral thesis As a doctoral student at LU, you use LUCRIS to regis

https://www.ub.lu.se/en/publish/doctoral-theses/register-and-publish-thesis - 2026-01-17

Researchers at Lund University can use agreements to publish open access with easy handling of the administrative processes and negotiated costs. Read more about the terms of the agreement here. About the agreementThe agreement allows open access publishing under negotiated terms in 25 hybrid journals and all open access journals published by AIP PublishingThe agreement covers all types of peer-re

https://www.ub.lu.se/en/publish/open-access/publishing-agreements-and-discounts/aip-publishing - 2026-01-17